SnoN and Ski trigger abnormal cell proliferation by blocking the Smad-complex.

TLS Online TPP Program

#Id: 8864

#XL - R Botany

Defects of cohesin’s gene expression regulation function are the cause of a group of diseases collectively called cohesinopathies.

TLS Online TPP Program

#Id: 8865

#XL - R Botany

The phosphorylation state of T14 and Y15 is controlled by a dual-specificity protein kinase known as Wee1 and a pair of dual-specificity phosphatases, Cdc25B and Cdc25C (Threonine 14 is not phosphorylated in S. pombe CDK1)

TLS Online TPP Program

#Id: 8866

#XL - R Botany

TLS Online TPP Program

#Id: 8867

#XL - R Botany

Cdc25B is act as a starter phosphatase that initiates CDK1 activation

Cdc25C is the workhorse phosphatase that activates the vast majority of cyclin-CDK1 complexes

TLS Online TPP Program

#Id: 8868

#XL - R Botany

TLS Online TPP Program

#Id: 8869

#XL - R Botany

Yeast cells with a defective wee1+ gene activate mitotic CDKs prematurely and premature entry into mitosis (smaller than normal cells