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TLS Online TPP Program

#Id: 9529


Plant viruses have small genomes; most encode only three to 10 proteins.

#XL - R Botany #Stress response #Part B Pointers
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TLS Online TPP Program

#Id: 9672

#XL - T Zoology

In unstimulated cells, 
concentration of phosphoinositides is low, and PKB is
inactive because its PH domain physically blocks the kinase active site

TLS Online TPP Program

#Id: 9673

#XL - T Zoology

Ligand-induced receptor activation,

Concentration of PI 3-phosphates rises

PH domain of PKB binds to PI 3-phosphates

TLS Online TPP Program

#Id: 9674

#XL - T Zoology

Maximal activation of PKB depends on recruitment to the cytosolic surface of the plasma membrane of two other kinases -PDK1 and PDK2.

TLS Online TPP Program

#Id: 9675

#XL - T Zoology

PDK1 can phosphorylate PKB on a critical threonine residue in its activation loop


TLS Online TPP Program

#Id: 9676

#XL - T Zoology

Phosphorylation by the mTORC2 kinase complex, of a second serine on
PKB that is not in the activation loop is necessary for maximal PKB activity


TLS Online TPP Program

#Id: 9677

#XL - T Zoology

Activated PKB directly phosphorylates and inactivates a protein Bad

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