Active Raf phosphorylates MEK on one or two serine residues in its activation loop, activating MEK kinase activity

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#Id: 9654

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Feedback regulation by MAP Kinase

activated MAP kinase phosphorylates the HER1 on a threonine residue near the juxtamembrane domain. 

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#XL - T Zoology

Feedback regulation by MAP Kinase

Phosphorylation of threonine residue in HER1 decreases the ability of the receptor kinase to become fully active.

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#Id: 9656

#XL - T Zoology

Feedback regulation by MAP Kinase

Active MAP kinase phosphorylates Raf on multiple sites, reducing its association with Ras.

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#Id: 9657

#XL - T Zoology

Negative feedback regulation by MAP Kinase

activated MAP kinase triggers an increase in the expression of dual-specificity phosphatases (DUSPs), particularly DUSP6.

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Hormonal stimulation of GPCR leads to the activation of PLC (IP3/DAG pathway).

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#XL - T Zoology

GPCRs specifically activate the β isoform of PLC (PLCβ)