Ligand-induced receptor activation,

Concentration of PI 3-phosphates rises

PH domain of PKB binds to PI 3-phosphates

TLS Online TPP Program

#Id: 9707

#XL - T Zoology

Ligand binding and dissociation of the G protein subunits, the membrane-tethered Gβγ subunit binds the Ste5.

TLS Online TPP Program

#Id: 9708

#XL - T Zoology

Ste5 acts as a scaffold for assembling other components in the cascade Ste11, Ste7, and Fus3.

TLS Online TPP Program

#Id: 9709

#XL - T Zoology

Gβγ activates Cdc24, a GEF for Cdc42

TLS Online TPP Program

#Id: 9710

#XL - T Zoology

Cdc24 = SOS

Cdc42 = Ras

TLS Online TPP Program

#Id: 9711

#XL - T Zoology

GTP-bound Cdc42, binds to and activates the Ste20 kinase.

TLS Online TPP Program

#Id: 9712

#XL - T Zoology

Ste20 serves as a MAPKKK kinase.