The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 

TLS Online TPP Program

#Id: 8887

#XL - T Zoology

The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 

TLS Online TPP Program

#Id: 9065

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The promoter or enhancer segments of all genes regulated by PKA contain a cis-acting DNA sequence, the cAMP-response element (CRE), which

contains the highly conserved nucleotide sequence,

5'-TGACGTCA-3'.

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#Id: 9066

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In nucleus PKA phosphorylate serine-133 on a transcription factor called CREbinding (CREB) protein

TLS Online TPP Program

#Id: 9067

#XL - T Zoology

Phosphorylated CREB binds to CRE-containing target genes and also binds to the co-activator termed CBP/P300, thereby stimulating gene transcription

TLS Online TPP Program

#Id: 9068

#XL - T Zoology

TLS Online TPP Program

#Id: 9069

#XL - T Zoology

Inactive PKA is a tetramer consisting of- 

two regulatory (R) subunits

two catalytic (C) subunits

TLS Online TPP Program

#Id: 9070

#XL - T Zoology

Two large classes of GTPase switch proteins are used in signal transduction pathways:

1. Heterotrimeric G proteins

2. Monomeric G proteins