Perception of MAMPs or DAMPs by cell surface PRRs is called Pathogen Triggered Immunity

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In nucleus PKA phosphorylate serine-133 on a transcription factor called CREbinding (CREB) protein

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Phosphorylated CREB binds to CRE-containing target genes and also binds to the co-activator termed CBP/P300, thereby stimulating gene transcription

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Inactive PKA is a tetramer consisting of- 

two regulatory (R) subunits

two catalytic (C) subunits

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Two large classes of GTPase switch proteins are used in signal transduction pathways:

1. Heterotrimeric G proteins

2. Monomeric G proteins

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Feedback mechanisms suppress signaling by the PKA pathway:

1. Intrinsic GTPase activity of Gαs

2. PDE acts to hydrolyze cAMP to 5′-AMP

3. By BARK