Natural immunity to helminth infections is Th2-type responses, including ILC2s, and IL-4 and IgE production.

TLS Online TPP Program

#Id: 9957

#XL - T Zoology

Wnts are paracrine factors that make up a large family of cysteine-rich glycoproteins

TLS Online TPP Program

#Id: 9958

#XL - T Zoology

Structure of Wnt proteins 

22 cysteine residues, which form disulfide bridges that maintain a globular secondary structure.

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#Id: 9959

#XL - T Zoology

Wnt = wingless + integrated

TLS Online TPP Program

#Id: 9960

#XL - T Zoology

Wnt proteins are modified by linkage of a monounsaturated fatty acid, palmitoleic acid, to a serine in the middle of the protein.

TLS Online TPP Program

#Id: 9961

#XL - T Zoology

Lipid modifications of Wnt are catalyzed by the 

O-acetyltransferase Porcupine.

TLS Online TPP Program

#Id: 9962

#XL - T Zoology

Principal signaling receptor is Frizzled (Fz), contains 

7 TM α helices.