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Increased Ca2+ levels activates Ca2+-dependent signaling molecules such as:
Protein kinase C, Ca2+/calmodulin-dependent protein kinase (CamKII), Calcineurin phosphatase

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Evolution
Evolution means descent with modification, or change in the form, physiology, and behavior of organisms over many generations of time. 

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Proximate causes - The subject of cell biology, neurobiology, and many other biological disciplines.
Ultimate causes - Their historical causes, especially the action of natural selection.

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Before Darwin - Christians interpreted “special creation”

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Carolus Linnaeus - Classified “related” species into genera, “related” genera into orders, and so on. 
To him, “relatedness” meant propinquity in the Creator’s design.

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