In 1988, Richardson and Richardson observed that certain amino acid residues are statically favored as the amino-terminal caps for the alpha helices in 45 globular proteins. Which of the following statement stand correct with stability of helix?

A. The introduction of a negatively charged side chain at the N-cap, which can neutralize the partial dipole created by the unpaired amide protons, has been shown to increase stability

B. In particular, Gly is often observed at the both C-cap position and N-cap positions

C. In particular, Gly is often observed at the C-cap position only

D. In particular, Gly is often observed at the C-cap position, Asn at the N-cap position, Pro at the Ncap+1 and Asp and Glu at N2 and N3

TLS Online TPP Program

#Question id: 24490

#Unit 3. Fundamental Processes

There are three type of Splicing signals 1. Major U2-type or GU-AG introns 2. Minor U12-type or AU-AC introns & 3. Minor U12-type with GU-AG introns (hybrid type), which of the following is responsible for the recognition of branch point sequence UACUAAC?

TLS Online TPP Program

#Question id: 24489

#Unit 3. Fundamental Processes

Two transesterification reactions takes place for 2 exon -1 intron configuration. Choose the correct  statement 

a. First transesterification is always caused by exon 1 -3’OH

b. second transesterification is catalysed variably either by external G or branch point while .

c. First transesterification is catalysed variably either by external G or branch point while 

d. second transesterification is always caused by exon 1 -3’OH.

TLS Online TPP Program

#Question id: 24464

#Unit 3. Fundamental Processes

rRNA are encoded by two type of RNA pol. RNA pol I and RNA pol III in which 5.8s rRNA is encodes by …………. While 5s rRNA encoded by ……

TLS Online TPP Program

#Question id: 4350

#Unit 3. Fundamental Processes

Portions of the DNA sequences of normal and mutant b-globin genes are shown. The most plausible explanation for why the indicated mutation (changing an A to a G) results in the disease b-thalassemia is that the mutation

TLS Online TPP Program

#Question id: 4349

#Unit 3. Fundamental Processes

RNA Pol IV and Pol V

TLS Online TPP Program

#Question id: 4122

#Unit 3. Fundamental Processes

RNA Pol uses its active site, in a simple back-reaction, to catalyze the removal of an incorrectly inserted ribonucleotide. This phenomenon known as