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TLS Online TPP Program

#Question id: 12482

The Rb protein has been called the “master brake” of the cell cycle. How the Rb protein acts as a cell cycle brake?

#Unit 2. Cellular Organization
  1. Rb bound to E2F and function as transcriptional repressors because Rb recruits chromatin-modifying enzymes that promote deacetylation and methylation of specific histone lysines, causing chromatin to assume a condensed, transcriptionally inactive form.
  2. S phase CDKs and mitotic CDKs maintain Rb protein in the phosphorylated state throughout the S, G2, and early M phases.
  3. Rb bound to E2F and promotes ubiquitinylation of E2F and inhibits chromosomal segregation.
  4. Rb bound to E2F and promotes acetylation which prevents unloading of cohesins.
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TLS Online TPP Program

#Question id: 5345

#Unit 8. Inheritance Biology

Which of the following above is most probable mode of inheritance?
TLS Online TPP Program

#Question id: 5346

#Unit 8. Inheritance Biology

The following typical pedigree illustrates the key point that affected children are born to unaffected parents: Which of the following is correct statement?
TLS Online TPP Program

#Question id: 5347

#Unit 8. Inheritance Biology

The inheritance of a given disorder is recorded in small families shown below: Based on the above limited information, which one of the following inheritance pattern best explains the observations?
TLS Online TPP Program

#Question id: 5363

#Unit 8. Inheritance Biology

A Southern blot using a probe that binds to the region spanning the mutation causing albinism detects one DNA fragment in homozygous normal individuals (A/A) and two fragments in albino individuals (a/a). Following banding pattern of three offspring of parents? Which of the following correct regarding parents?
TLS Online TPP Program

#Question id: 5357

#Unit 8. Inheritance Biology

This pedigree shows the inheritance of a recessive trait in humans. Individuals that have the trait are homozygous for a recessive allele a. If H and I, who happen to be first cousins, marry and have a child, what is the chance that this child will have the recessive trait?
TLS Online TPP Program

#Question id: 5356

#Unit 8. Inheritance Biology

In the following pedigree, individuals with shaded circle or shaded square show presence of a recessive autosomal trait. The calculated risk of occurrence of this trait for III-I is