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TLS Online TPP Program

#Question id: 4110

Tay-Sachs disease belongs to the family of lysosomal storage diseases; it is an autosomal recessive neurodegenerative disorder caused by deficiency of the lysosomal enzyme hexosaminidase. The inability to degrade sphingolipids results in the deposition of these lipids in the cells that causes severe mental retardation and death in childhood. The most common mutation in Tay-Sachs disease patients is a 4-base pair insertion in exon 11 of the 14 exons of the hexosaminidase gene. What could be the most likely consequence of this mutation?

#Unit 3. Fundamental Processes

  1. RNA polymerase II cannot bind to the hexosaminidase promoter.

  2. Termination of transcription of the gene is impaired.

  3. Hexosaminidase mRNA is unable to bind to ribosomes.

  4. The C-terminal region of the protein has an abnormal amino acid sequence.

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TLS Online TPP Program

#Question id: 23640

#General Aptitude

I was quite alone in the park. After some time an old man and an old woman came there. After them two couples with a baby came there. Now, how many persons are there?
TLS Online TPP Program

#Question id: 23639

#General Aptitude

There are three pillars X, Y and Z of different heights. There spiders A, B and C start of climb on these pillars simultaneously. In one chance A climbs on X by 5 cm but slips down 1 cm. B climbs on Y 6 cm but slips down 3 cm. C climbs on Z 7 cm but slips down 2 cm. If they each requires 50 chances to reach the top of the pillar, what is the height of the shortest pillar?
TLS Online TPP Program

#Question id: 23638

#General Aptitude

The minimum number of colours required to paint all the sides of a cube so that no two adjacent faces may have the same colour, is
TLS Online TPP Program

#Question id: 23637

#General Aptitude

How many numbers from 1 to 100 are such each which is divisible by 8 and whose at least one digit is 8?
TLS Online TPP Program

#Question id: 23636

#General Aptitude

A, B, C, D and E distribute some cards among themselves in a manner that A gets one less than B; C gets 5 more than D; E gets 3 more than B while D gets as many as b. who gets the least number of cards?
TLS Online TPP Program

#Question id: 23635

#General Aptitude

Three individuals X, Y, Z hired a car on a sharing basis and paid Rs. 1, 040. They used it for 7, 8, 11 hours, respectively. What are the charges paid by Y?