Tumor-suppressor genes generally encode proteins that in one way or another inhibit cell proliferation. Loss-of-function mutations in one or more of these proliferation inhibitory proteins contribute to the development of many cancers. Prominent among the classes of proteins encoded by tumor-suppressor genes are:

A. Intracellular proteins that regulate or inhibit entry into the cell cycle

B. Receptors or signal transducers for secreted hormones or developmental signals that inhibit cell proliferation

C. Checkpoint pathway proteins that arrest the cell cycle if DNA is damaged

D. Proteins that promote apoptosis

Following genes belongs to the above class-

i. p53

ii. Rb

iii.TGF- β

iv. Caspase 3 and 7

which of the following match is correct?

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#Question id: 5450

#Unit 8. Inheritance Biology

Which of these definitions of heritability is most correct?

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#Question id: 5751

#Unit 8. Inheritance Biology

A biochemical mutant that must be supplied with a particular nutrient for growth would be described as a(n)

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#Question id: 5346

#Unit 8. Inheritance Biology

The following typical pedigree illustrates the key point that affected children are born to unaffected parents: Which of the following is correct statement?

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#Question id: 13144

#Unit 8. Inheritance Biology

Shell coiling of the snail Limnaea peregra(genetic maternal effect)  the shell coils (s+s+) which is termed dextral coiling, while some snails exhibiting sinistral coiling (ss). The allele for dextral (s +) is dominant over the allele for sinistral (s). If a male homozygous for dextral alleles (s+s+) is crossed with a female homozygous for sinistral alleles (ss) all of the F1 are heterozygous (s+s) and have a sinistral shell. If these F1 snails are self-fertilized, what is the phenotype of the F2 snail?

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#Question id: 12169

#Unit 8. Inheritance Biology

During the phenotypic variations, the genotype shows variation at different effect given in graph;

According to the graph , this is an example of,

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#Question id: 12168

#Unit 8. Inheritance Biology

The proportion of the total phenotypic  variation that is due to genetic differences is known as