Following statements are regarding to the apoptosis which is induced by trophic factors.

A. The presence of specific trophic factors (e.g., NGF) leads to activation of their cognate receptor tyrosine kinases (e.g., TrkA) and activation of the PKB pathway.

B. DNA damage or ultraviolet irradiation leads to induction of synthesis of the BH3-only Puma protein. Puma binds to Bak and Bax as well as to Bcl-2, allowing Bak and Bax to form oligomeric pores.

C. Removal of a cell from its substratum disrupts integrin signaling, leading to release of the BH3-only Bim protein from the cytoskeleton.

D. Binding of extracellular death signals, such as tumor necrosis factor and Fas ligand, to their receptors oligomerizes an associated protein (FADD), which in turn triggers the caspase cascade, leading to cell murder by apoptosis.

Which of the following pathway does not belong to the trophic factor inducing apoptotic pathway?

#Question id: 12693

#Unit 8. Inheritance Biology

#Question id: 4899

#Unit 8. Inheritance Biology

In Neurospora a cross between the genotypes 'A' and 'a' results in an ascus with ascospores of genotypes as shown below: 

 Statements A to D are events that could have occurred during meiosis.

A) Class I is results of no crossing over between the centromere and gene.

B) Class II is results of single crossing over between the centromere and gene

C) Class I shows segregation of alleles 'A' and 'a' in meiosis II

D) Class II shows segregation of alleles 'A' and 'a' in meiosis II

#Question id: 4898

#Unit 8. Inheritance Biology

A three point test cross was carried out in Drosophila melanogaster involving three adjacent genes A, B and C. arranged in the same order. The distance between A to B is 15 map unit (mu) and that between B to C is 30 map. The coefficient of coincidence = 0.67. What is the percentage of double recombinants in the progeny obtained from the testcross?

#Question id: 4897

#Unit 8. Inheritance Biology

When two independent pure lines AAbb and aaBB of pea with white flowers are crossed, the F1 progeny has purple flowers. Gene A and B link at 20 map unit. The following conclusions were made

A. When an heterozygous individual of the genotype AaBb is test crossed, progenies with purple and white in a ratio of 1:3

B. When an heterozygous individual of the genotype AaBb is test crossed, progenies with purple and white in a ratio of 1:9

C. This is an example of complementary gene action

D. The F2 progeny obtained on selfing shows both pruple and white flower in a ratio of 9:7                                            

Which of the following conclusions are correct?

#Question id: 4896

#Unit 8. Inheritance Biology

A cross between individuals with genotypes AaBbX aabb produces the following progeny:

AaBb -  21, aaBb- 83, Aabb-   77,  aa bb -19

Which of the following statements is true?

a) Map unit between gene A and B

b) Configuration

c) parents genotype of AaBb

#Question id: 4895

#Unit 8. Inheritance Biology

What is the difference between a linkage map and a physical map?

a) Genetic maps are based on recombination frequencies, but physical maps are based on restriction digestion.

b) Physical DNA map describes the absolute position of genes on a chromosome while genetic map so variable

c) Genetic maps are important to identify the origin of diseases, whether they are inherited or arise due to a random mutation.