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TLS Online TPP Program

#Question id: 1045

Why would it be more difficult to treat diseases in humans caused by members of the Eukarya than diseases caused by the Bacteria?

#SCPH28 | Zoology

  1. Multicellular organisms always have their own immune systems to contend with-so any treatment we develop needs to overcome this built-in protection mechanism in such organisms.

  2. Since bacteria are so much simpler (being single-celled), they are inherently easier to kill off than multi-cellular eukaryotic microbes.

  3. Eukaryotic microbes use many of the same enzymes and systems as humans-so we lose the ability to target certain molecules that might be present ONLY in the cell type we want to eliminate. There's too much overlap when both organisms are eukaryotic.

  4. Eukaryotic microbes (unlike prokaryotes) often secrete compounds that breakdown and eliminate drugs used against them. This makes them much harder to effectively eliminate than bacteria.

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TLS Online TPP Program

#Question id: 14292

#SCPH05 I Biotechnology

Consider the scale up of a fermentation from a 10L to 10000L while maintaining geometric similarity. Agitation speed was maintained at 500 rpm in the 10L fermenter. If scale up is done based on constant tip speed, then the agitation speed in the larger reactor should be 
rpm. 
TLS Online TPP Program

#Question id: 14293

#SCPH05 I Biotechnology

Scale up of a fermenter is done based on constant impeller tip speed. If the diameter of the impeller is increased by 10-fold, the agitator speed will: 
TLS Online TPP Program

#Question id: 14293

#SCPH05 I Biotechnology

Scale up of a fermenter is done based on constant impeller tip speed. If the diameter of the impeller is increased by 10-fold, the agitator speed will: 
TLS Online TPP Program

#Question id: 14294

#SCPH05 I Biotechnology

What will be the generation time of a culture with a specific growth rate constant of 0.01 min^-1? 
TLS Online TPP Program

#Question id: 14294

#SCPH05 I Biotechnology

What will be the generation time of a culture with a specific growth rate constant of 0.01 min^-1? 
TLS Online TPP Program

#Question id: 14295

#SCPH05 I Biotechnology

Pseudomonas methylotrophus is used to produce single-cell protein from methanol in a 1000 m3 pressure-cycle airlift fermenter. The biomass yield from substrate is 0.41 g g- 1, KS is 0.7 mg l- 1, and the maximum specific growth rate is 0.44 h- 1. The medium contains 4% (w/v) methanol. A substrate conversion of 98% is desirable. The reactor may be operated either in batch or continuous mode. If operated in batch, an inoculum of 0.01% (w/v) is used and the downtime between batches is 20 h. If operated continuously, a downtime of 25 d is expected per year. Neglecting maintenance requirements, compare the annual biomass production from batch and continuous reactors?

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