Sonic hedgehog is responsible for assuring that motor neurons come only from the ventral portion of the neural tube & essential for normal patterning of the limbs

TLS Online TPP Program

#Id: 1574

#Unit 4. Cell Communication and Cell Signaling

Binding of Wnt to its receptor Frizzled (Fz) and to the LRP co-receptor triggers phosphorylation of LRP by GSK3 and CK1, enables Axin to bind LRP & Dsh.

 

TLS Online TPP Program

#Id: 1575

#Unit 4. Cell Communication and Cell Signaling

Binding of Axin to the phosphorylated LRP protein and to Dishevelled disrupts the Axin–APC–CK1–GSK3–β-catenin complex. 

TLS Online TPP Program

#Id: 1576

#Unit 4. Cell Communication and Cell Signaling

Unphosphorylated β-catenin translocates to the nucleus.

TLS Online TPP Program

#Id: 1577

#Unit 4. Cell Communication and Cell Signaling

β-catenin binds to TCF to displace the Gro repressor and recruits co-activator proteins Pygo, LGS, to activate target gene expression.

TLS Online TPP Program

#Id: 1578

#Unit 4. Cell Communication and Cell Signaling

Active Wnt signaling leads to the secretion of Notum.

 

TLS Online TPP Program

#Id: 1579

#Unit 4. Cell Communication and Cell Signaling

Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.