Increased [Ca2+]cyt activates plasma membrane anion efflux channels, and these two effects combine to depolarize the membrane. Membrane depolarization closes voltage‐sensitive K+ in channels but opens K+ out channels. 

TLS Online TPP Program

#Id: 413

#Unit 2. Cellular Organization

H2AX is normally present in only 10%–15% of the nucleosomes in multicellular eukaryotes

TLS Online TPP Program

#Id: 414

#Unit 2. Cellular Organization

H2AX subtype is has a C-terminal tail that is distinct from the canonical H2A, characterized by a SQEL/Y motif at the end.

TLS Online TPP Program

#Id: 415

#Unit 2. Cellular Organization

SQEL/Y motif of H2AX is phosphorylated by ATM/ATR kinases, activated by DNA damage, is involved in DNA repair

TLS Online TPP Program

#Id: 416

#Unit 2. Cellular Organization

H2AX phosphorylated at the SQEL/Y motif is sometimes referred to as “gamma-H2AX,”

TLS Online TPP Program

#Id: 417

#Unit 2. Cellular Organization

Gamma-H2AX frequently functions in DSBR

TLS Online TPP Program

#Id: 418

#Unit 2. Cellular Organization

H2AZ variant has 60% sequence identity with canonical H2A and involved in gene activation, heterochromatin–euchromatin boundary formation, cell-cycle progression.