T cells initiate the adaptive immune response by interacting MHC on antigen-presenting cells that have been exposed to pathogens. 

TLS Online TPP Program

#Id: 10386

#Unit 4. Cell Communication and Cell Signaling

Presentation of nonpeptide antigens derived from pathogens involves the nonclassical class I–like CD1 molecule

TLS Online TPP Program

#Id: 10387

#Unit 4. Cell Communication and Cell Signaling

Class I presentation requires internal synthesis of virus protein, as shown by the requirement that the target cell be infected by live virus, and by the inhibition of class I presentation observed when protein synthesis was blocked by the inhibitor emetine.

TLS Online TPP Program

#Id: 10388

#Unit 4. Cell Communication and Cell Signaling

Class II presentation can occur with either live or replication-incompetent virus; protein synthesis inhibitors had no effect, indicating that new protein synthesis is not a necessary condition of class II presentation. 

TLS Online TPP Program

#Id: 10389

#Unit 4. Cell Communication and Cell Signaling

Class II, but not class I, presentation is inhibited by treatment of the cells with an agent that blocks endocytic processing within the cell (chloroquine).

TLS Online TPP Program

#Id: 83

#Unit 5. Developmental Biology

Fate map, 

A diagram that “maps” the larval or adult structures onto the region of the embryo from which they arose.

TLS Online TPP Program

#Id: 84

#Unit 5. Developmental Biology

Commitment

The commitment of cells to specific cell fates & their capacity to differentiate into particular kinds of cells (cell has began in a direction towards a specific fate).