The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 1481

#Unit 4. Cell Communication and Cell Signaling

Let-7 miRNAs down-regulate the translation of Ras. Thus in the absence of the miRNAs, Ras is constitutively overproduced, contributing to tumorigenesis.

TLS Online TPP Program

#Id: 7509

#Unit 6. System Physiology – Plant

TLS Online TPP Program

#Id: 8159

#Unit 2. Cellular Organization

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 6258

#Unit 8. Inheritance Biology

ene Interaction Takes Place When Genes at Multiple Loci Determine a Single Phenotype.

TLS Online TPP Program

#Id: 3490

#Unit 12. Applied Biology

Gibberellins (0.1-1mg/l) promotes shoot elongation and Somatic embryo germination.