Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7(CD80/86)

ICAM-1

MHC-1 and 2 both

CD 22

TLS Online TPP Program

#Id: 8929

#Unit 2. Cellular Organization

Chk1, Chk2, and MK2

cause cell cycle arrest by inhibiting Cdc25

stabilizing the transcription factor p53, which induces the transcription of CKI p21 

TLS Online TPP Program

#Id: 8930

#Unit 2. Cellular Organization

If the DNA damage is severe, p21 can cause the cells to senesce or p53 can induce apoptosis.

TLS Online TPP Program

#Id: 8931

#Unit 2. Cellular Organization

DNA-PK, ATM, and ATR phosphorylate a variant histone H2AX within the chromatin near the damage site & Phosphorylated H2AX acts as a landing pad for recruiting additional protein complexes that control DNA repair

TLS Online TPP Program

#Id: 8932

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8933

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8934

#Unit 2. Cellular Organization

Spindle assembly checkpoint pathway is active until every single kinetochore has attached properly to spindle microtubules