Gain-of-function mutations:

1. Duplication or amplification of the gene

2. A point mutation that results in a hyperactive or constitutively active protein product

TLS Online TPP Program

#Id: 7403

#Unit 5. Developmental Biology

Cytoplasmic inhibitor protein of dorsal is Cactus.

TLS Online TPP Program

#Id: 7404

#Unit 5. Developmental Biology

Dorsal protein enters the nucleus and ventralizes the cell

TLS Online TPP Program

#Id: 7405

#Unit 5. Developmental Biology

Dorsal protein is a transcription factor that activates the genes that generate the ventrum.

TLS Online TPP Program

#Id: 7406

#Unit 5. Developmental Biology

The highest concentrations of Dorsal in the most ventral cell nuclei, become the mesoderm

TLS Online TPP Program

#Id: 7407

#Unit 5. Developmental Biology

The segment polarity genes encode proteins that are constituents of the Wnt and Hedgehog signaling pathways.

TLS Online TPP Program

#Id: 7408

#Unit 5. Developmental Biology

The engrailed gene is activated in cells that have high levels of the Even-skipped, Fushi tarazu, or Paired & repressed in cells that have high levels of Odd-skipped, Runt, or Sloppy-paired