Benzo(a)pyrene

(found in cigarette smoke & coal tar) undergoes metabolic activation by cytochrome P-450 in the lungs to form a potent mutagen

TLS Online TPP Program

#Id: 6077

#Unit 10. Ecological Principles

Vulnerability to extinction can be linked to species characteristics

TLS Online TPP Program

#Id: 8931

#Unit 2. Cellular Organization

DNA-PK, ATM, and ATR phosphorylate a variant histone H2AX within the chromatin near the damage site & Phosphorylated H2AX acts as a landing pad for recruiting additional protein complexes that control DNA repair

TLS Online TPP Program

#Id: 5410

#Unit 7. System Physiology – Animal

Microglia 

arise from macrophages outside of the nervous system are scavenger cells that resemble tissue macrophages and remove debris resulting from injury, infection, and disease.

TLS Online TPP Program

#Id: 2170

#Unit 11. Evolution and Behavior

The components of fitness are survival and reproduction.

TLS Online TPP Program

#Id: 3982

#Unit 2. Cellular Organization

Camptothecin is an inhibitor of eukaryotic type I topoisomerases.

Irinotecan (Campto) and topotecan (Hycamtin)—used to treat colorectal cancer and ovarian cancer.

All these drug's act by trapping the topoisomerase-DNA complex in which the DNA is cleaved, inhibiting religation.