A classic inherited cancer syndrome is retinoblastoma, which is caused by loss of function of RB.

TLS Online TPP Program

#Id: 3036

#Unit 3. Fundamental Processes

The helicase DnaB is responsible for interacting with the primase DnaG to initiate each Okazaki fragment.

TLS Online TPP Program

#Id: 3037

#Unit 3. Fundamental Processes

DnaB is responsible for forward movement at the replication fork.

TLS Online TPP Program

#Id: 3038

#Unit 3. Fundamental Processes

Core polymerase and the clamp dissociate at completion of Okazaki fragment synthesis and reassociate at the beginning.

TLS Online TPP Program

#Id: 3039

#Unit 3. Fundamental Processes

The length of the priming RNA is limited to eight to 14 bases. Apparently, DNA polymerase III is responsible for displacing the primase.

TLS Online TPP Program

#Id: 3040

#Unit 3. Fundamental Processes

DNA ligase makes the bond that connects the 3 ' end of one Okazaki fragment to the 5 ' beginning of the next fragment.

TLS Online TPP Program

#Id: 3041

#Unit 3. Fundamental Processes

Synthesis of an Okazaki fragment terminates just before the start of the RNA primer of the preceding fragment.