A classic inherited cancer syndrome is retinoblastoma, which is caused by loss of function of RB.

TLS Online TPP Program

#Id: 1758

#Unit 4. Cell Communication and Cell Signaling

Class II, but not class I, presentation is inhibited by treatment of the cells with an agent that blocks endocytic processing within the cell (chloroquine).

TLS Online TPP Program

#Id: 1759

#Unit 4. Cell Communication and Cell Signaling

Mechanisms to protect an individual from this sort of anti-self immune attack must exist, and they do, called as tolerance

TLS Online TPP Program

#Id: 1760

#Unit 4. Cell Communication and Cell Signaling

Self-tolerance involving both the elimination of immune cells that can react against self-antigens and active inhibition of immune responses.

TLS Online TPP Program

#Id: 1761

#Unit 4. Cell Communication and Cell Signaling

Self-reactive B cells can undergo receptor editing.

In this process, the antigen-specific V region is “edited” or switched for a different V-region gene segment via V(D)J recombination,

TLS Online TPP Program

#Id: 1762

#Unit 4. Cell Communication and Cell Signaling

Central tolerance deletes self-reactive T- or B-cell clones before the cells are allowed to mature. occurs in the primary lymphoid organs

TLS Online TPP Program

#Id: 1763

#Unit 4. Cell Communication and Cell Signaling

Peripheral tolerance, which renders some self-reactive lymphocytes in secondary lymphoid tissues inactive and generates others that actively inhibit immune responses against self