Inherited a single mutant NF1 allele then develop neurofibromas, a benign tumor of the sheath cells that surround nerves, caused by loss of both alleles through LOH.

TLS Online TPP Program

#Id: 3702

#Unit 2. Cellular Organization

The proportion of DNA containing protein-coding genes being expressed in a specific cell at a specific time can be determined by the amount of the DNA that can hybridize with the mRNAs isolated from that cell called as RoT analysis

TLS Online TPP Program

#Id: 3703

#Unit 2. Cellular Organization

Highly repetitive DNA (or satellite DNA) has a very short repeating sequence and no coding function.

Satellite DNA is often the major constituent of centromeric heterochromatin

TLS Online TPP Program

#Id: 3704

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 3705

#Unit 2. Cellular Organization

Many genes are arranged along the chromosomes in groups of related genes. These groups are called gene clusters. Examples of gene clusters are the globin gene family.

TLS Online TPP Program

#Id: 3706

#Unit 2. Cellular Organization

When a genome contains a cluster of genes with related sequences, mispairing between nonallelic loci can cause unequal crossing over. This produces a deletion in one recombinant chromosome and a corresponding duplication in the other.

TLS Online TPP Program

#Id: 3707

#Unit 2. Cellular Organization

Thalassemias result from occurrence of unequal crossing that reduce or prevent synthesis of either a- or b-globin