BH3-only proteins: Regulate activity of Bcl-2 and Bax/Bak proteins

Bim, Puma, Noxa, Bik, Bmf, Bad, Hrk, Bid

TLS Online TPP Program

#Id: 6280

#Unit 3. Fundamental Processes

Core enzyme binds indiscriminately to any DNA. Sigma factor reduces the affinity for sequence-independent binding and confers specificity for promoters.

TLS Online TPP Program

#Id: 6281

#Unit 3. Fundamental Processes

Holoenzyme binds to promoters much more tightly, with an association constant ,1000 times higher on average and a half-life that can be as long as several hours

TLS Online TPP Program

#Id: 6282

#Unit 3. Fundamental Processes

significantly higher dissociation rate at 25C than at 37C, and a much higher dissociation rate at 15C. Because high temperature promotes DNA melting

TLS Online TPP Program

#Id: 6283

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6284

#Unit 3. Fundamental Processes

Mechanism: How Polymerase Find Promoter Sequences

TLS Online TPP Program

#Id: 6285

#Unit 3. Fundamental Processes