Inhibitory Proteins in Cell Cycle-

Sic1 - Binds and inhibits S phase CDKs

CKIs p27, p57, and p21- Bind and inhibit CDKs

INK4 - Binds and inhibits G1 CDKs

Rb - Binds E2Fs

TLS Online TPP Program

#Id: 10504

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 protein = C. elegans CED-9 protein

(23% identical in aa sequence)

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#Id: 10505

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins act as regulators that suppress the apoptotic pathway

TLS Online TPP Program

#Id: 10506

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins contain a single TM domain and are localized to the outer mitochondrial membrane

TLS Online TPP Program

#Id: 10507

#Unit 4. Cell Communication and Cell Signaling

CED-9 protein, forms a complex with a dimer of the CED-4 protein, preventing the CED-4 protein from activating the CED-3 protease

TLS Online TPP Program

#Id: 10508

#Unit 4. Cell Communication and Cell Signaling

CED-4 is a protease-activating factor that causes autoproteolytic cleavage of the CED-3 protease to promote its activation and to initiate cell death

TLS Online TPP Program

#Id: 10509

#Unit 4. Cell Communication and Cell Signaling

CED-4 in C. elegans = Apaf-1 in Mammals