Inhibitory Proteins in Cell Cycle-

Sic1 - Binds and inhibits S phase CDKs

CKIs p27, p57, and p21- Bind and inhibit CDKs

INK4 - Binds and inhibits G1 CDKs

Rb - Binds E2Fs

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#Id: 7400

#Unit 5. Developmental Biology

GD cleaves Snake to its active form and forms a complex with Snake and uncleaved Easter proteins.

Easter protein is cleaved into its

active form.

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#Id: 7401

#Unit 5. Developmental Biology

Cleaved Easter binds to and cleaves Spätzle; activated Spätzle binds to Toll receptor protein

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#Id: 7402

#Unit 5. Developmental Biology

Toll activation activates Tube and Pelle, which phosphorylate the Cactus protein. Cactus is degraded, releasing it from Dorsal.

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#Id: 7403

#Unit 5. Developmental Biology

Cytoplasmic inhibitor protein of dorsal is Cactus.

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#Id: 7404

#Unit 5. Developmental Biology

Dorsal protein enters the nucleus and ventralizes the cell

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#Id: 7405

#Unit 5. Developmental Biology

Dorsal protein is a transcription factor that activates the genes that generate the ventrum.