Neurotransmitter release from the rods of retina- Glutamate

TLS Online TPP Program

#Id: 10062

#Unit 4. Cell Communication and Cell Signaling

In cis interactions (intracellular or lateral interactions)

monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane

TLS Online TPP Program

#Id: 10063

#Unit 4. Cell Communication and Cell Signaling

CAMs fall into one of four major families: 

Cadherins

Immunoglobulin (Ig) superfamily

Integrins

Selectins

TLS Online TPP Program

#Id: 10064

#Unit 4. Cell Communication and Cell Signaling

The adhesiveness of cadherins depends on the presence of extracellular Ca2+

TLS Online TPP Program

#Id: 10065

#Unit 4. Cell Communication and Cell Signaling

Two type of Cadherins:

1. Classical cadherin proteins

2. Nonclassical cadherin proteins

TLS Online TPP Program

#Id: 10066

#Unit 4. Cell Communication and Cell Signaling

Extracellular region of a classical cadherin contains five copies of the cadherin domain separated by flexible hinge regions

TLS Online TPP Program

#Id: 10067

#Unit 4. Cell Communication and Cell Signaling

Ca2+ ions bind to sites near each hinge and prevent it

from flexing, so that the whole string of cadherin domains behaves as a rigid and slightly curved rod to generate cell–cell adhesion