JAK kinases phosphorylate several tyrosine residues on the cytosolic domain of the cytokine receptor.

TLS Online TPP Program

#Id: 2657

#Unit 7. System Physiology – Animal

In the thick segment of the ascending loop of Henle  reabsorption mechanism is load-dependent.

TLS Online TPP Program

#Id: 2658

#Unit 7. System Physiology – Animal

In the thick segment of the ascending loop of Henle 

Reabsorption of solutes is closely linked to the reabsorptive capability of the sodium-potassium ATPase pump, which maintains a low intracellular

sodium concentration.

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#Id: 2659

#Unit 7. System Physiology – Animal

In the thick ascending loop, 

Luminal membrane contains a three-ion cotransporter  known as Na+-K+-2Cl- cotransporter

TLS Online TPP Program

#Id: 2660

#Unit 7. System Physiology – Animal

The energy for Na+-K+-2Cl- cotransporter is derived from the low intracellular Na+ gradient, which is maintained by the Na+-K+ ATPase

TLS Online TPP Program

#Id: 2661

#Unit 7. System Physiology – Animal

Thick ascending limb is called the diluting segment because NaCl is reabsorbed but water is not reabsorbed along with it.

TLS Online TPP Program

#Id: 2662

#Unit 7. System Physiology – Animal

The tubular fluid that leaves the thick ascending limb has a lower Na+ concentration and a lower osmolarity than blood.