Nurturing Life Sciences
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#Unit 7. System Physiology – Animal
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Negative chronotropic effects are decreases in heart rate.
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Stimulation of the sympathetic cardiac nerves speeds the depolarization in SA node.
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The rate of spontaneous discharge increases Norepinephrine secreted by the sympathetic endings binds to β1 receptors
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Increase in intracellular cAMP facilitates the opening of L channels, increasing ICa and the rapidity of the depolarization phase of the impulse.
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