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TLS Online TPP Program

#Id: 1575

Binding of Axin to the phosphorylated LRP protein and to Dishevelled disrupts the Axin–APC–CK1–GSK3–β-catenin complex. 


#Unit 4. Cell Communication and Cell Signaling #Signal transduction pathways #Part B Pointers
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TLS Online TPP Program

#Id: 7958

#Unit 2. Cellular Organization

The efficient formation of disulfide bonds in the lumen of the ER depends on the enzyme protein disulfide isomerase (PDI), which is present in all eukaryotic cells
TLS Online TPP Program

#Id: 7959

#Unit 2. Cellular Organization

Unfolded-protein response
Key protein –Ire1 promotes formation of Hac1
TLS Online TPP Program

#Id: 7960

#Unit 2. Cellular Organization

Binding of BiP to the luminal domain of monomeric Ire1 prevents formation of the Ire1 dimer.
TLS Online TPP Program

#Id: 7961

#Unit 2. Cellular Organization

Quantity of free BiP in the ER lumen determines the relative proportions of monomeric and dimeric Ire1.
TLS Online TPP Program

#Id: 7962

#Unit 2. Cellular Organization

Hac1 activates transcription of genes encoding several protein-folding catalysts.
TLS Online TPP Program

#Id: 7963

#Unit 2. Cellular Organization

A hereditary form of emphysema illustrates the detrimental effects that can result from misfolding of proteins in the ER.