Unfolded-protein response

Key protein –Ire1 promotes formation of Hac1

TLS Online TPP Program

#Id: 1413

#Unit 4. Cell Communication and Cell Signaling

When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 1414

#Unit 4. Cell Communication and Cell Signaling

The CaM*-Ca2+ complex binds and activates MLC kinase, phosphorylates the myosin LC. 

TLS Online TPP Program

#Id: 1415

#Unit 4. Cell Communication and Cell Signaling

The CaM*-Ca2+ complex binds and activates MLC kinase, phosphorylates the myosin LC. 

TLS Online TPP Program

#Id: 1416

#Unit 4. Cell Communication and Cell Signaling

Phosphorylation of MLC  unfolds the myosin II, active and can assemble into bipolar filaments for contraction. 

TLS Online TPP Program

#Id: 1417

#Unit 4. Cell Communication and Cell Signaling

When the Ca2+ levels drop: Myosin LC is dephosphorylated by MLC phosphatase, causing muscle relaxation.

TLS Online TPP Program

#Id: 1418

#Unit 4. Cell Communication and Cell Signaling

Integrins are the principal receptors used by animal cells to bind to the extracellular matrix.