Directional selection leads to fixation of the favored allele and elimination of the other allele.

TLS Online TPP Program

#Id: 2905

#Unit 3. Fundamental Processes

DnaA then acts at three A-T-rich 13 -bp tandem repeats located on the left side of oriC

TLS Online TPP Program

#Id: 2906

#Unit 3. Fundamental Processes

Two to four monomers of Dna AA TP bind at the origin, and after release of DiaA, they recruit two "pre-priming" complexes of the DnaB helicase bound to DnaC-ATP, so that there is one DnaB-DnaC-ATP complex for each of the two (bidirectional) replication forks.

TLS Online TPP Program

#Id: 2907

#Unit 3. Fundamental Processes

The function of DnaC is that of a chaperone to repress the helicase activity of DnaB until it is needed.

TLS Online TPP Program

#Id: 2908

#Unit 3. Fundamental Processes

Each DnaB-DnaC complex consists of six DnaC monomers bound to a hexamer of DnaB

TLS Online TPP Program

#Id: 2909

#Unit 3. Fundamental Processes

he prepriming complex generates a protein aggregate of 480 kD, which corresponds to a sphere of radius 6 nm

TLS Online TPP Program

#Id: 2912

#Unit 3. Fundamental Processes

Each DnaB activates a DnaG primase-in one case to initiate the leading strand, and in the other to initiate the first Okazaki fragment of the lagging strand