Regeneration blastema forms from pluripotent stem cells called clonogenic neoblasts (cNeoblasts).

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#Unit 5. Developmental Biology

Properties of epithelial-mesenchymal interactions:

Regional specificity of induction

Genetic specificity of induction

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#Id: 180

#Unit 5. Developmental Biology

Regional specificity of induction:

mesenchyme plays an instructive role, calling into play different sets of genes in the responding epithelial cells.

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#Unit 5. Developmental Biology

Genetic specificity of induction:

mesenchyme may instruct the epithelium as to what sets of genes to activate, the responding epithelium can comply with these instructions only so far as its genome permits.

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#Unit 5. Developmental Biology

Epithelial-Mesenchymal Transition

An orderly series of events whereby epithelial cells are transformed into mesenchymal cells.

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#Unit 5. Developmental Biology

Morphogen is a diffusable biochemical molecule that can determine the fate of a cell by its concentration.

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#Unit 5. Developmental Biology

Morphogens can be:

Transcription factors

Paracrine factors