The duration of primer extension is usually 2 min at 72°C

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#Id: 1024

#Unit 5. Developmental Biology

Intermediate levels of BMP effect the formation of the neural crest cells.

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#Id: 1025

#Unit 5. Developmental Biology

In mammals, Noggin (antagonist of BMP) is expressed in the notochord and neural folds.

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#Id: 1026

#Unit 5. Developmental Biology

Neural plate formation follow the principle of development:  often the signals promoting the specification of one cell type also block the specification of an alternative cell type.

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#Id: 1027

#Unit 5. Developmental Biology

The cells of the neural plate expresses:  Sox family of transcription factors (Sox1, 2, and 3)

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#Id: 1028

#Unit 5. Developmental Biology

Sox family of transcription factors

Inhibit the formation of epidermis and neural crest by blocking the transcription and signaling of BMPs

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#Id: 1029

#Unit 5. Developmental Biology

There are two principal modes of neurulation: 

1. Primary neurulation

2. Secondary neurulation