TLS Online TPP Program

#Id: 1383

#Unit 4. Cell Communication and Cell Signaling

Formin protein nucleate the assembly of unbranched filaments, (FH1 and FH2 domains-Actin nucleation by the formin FH2 domain).

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase.

The Arp2/3 Complex Nucleates Branched Filament Assembly.

TLS Online TPP Program

#Id: 1384

#Unit 4. Cell Communication and Cell Signaling

Toxins affect the dynamics of actin polymerization; some, 

Latrunculin

Phalloidin

Cytochalasin D

Jasplakinolide

TLS Online TPP Program

#Id: 1385

#Unit 4. Cell Communication and Cell Signaling

There are three classes of myosins, are present in many eukaryotes: 

Myosin I- single head domain

Myosin II- two heads and assembles into bipolar filaments

Myosin V- two heads but does not assemble into filaments

TLS Online TPP Program

#Id: 1386

#Unit 4. Cell Communication and Cell Signaling

The length of the myosin II neck domain determines the rate of movement.

TLS Online TPP Program

#Id: 1387

#Unit 4. Cell Communication and Cell Signaling

Skeletal muscle contraction is subject to thin-filament regulation.

TLS Online TPP Program

#Id: 1388

#Unit 4. Cell Communication and Cell Signaling

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain (LC) activation.