An excited fluorescent molecule such as GFP or YFP can dispose of the energy from the absorbed photon in either of two ways: 

by fluorescence, emitting a photon of slightly longer wavelength (lower energy) than the exciting light, or 

by nonradiative fluorescence resonance energy transfer (FRET).

TLS Online TPP Program

#Id: 10348

#Unit 4. Cell Communication and Cell Signaling

BAFF-R expression is first detected in T1 B cells and increases steadily there after.

Signaling through the BAFF/BAFF-R axis promotes survival of transitional B cells by inducing the synthesis of anti-apoptotic factors such as Bcl-2, Bcl-xl, and Mcl-1

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#Id: 10349

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10350

#Unit 4. Cell Communication and Cell Signaling

B cells migrate to the lymphoid follicles. They are directed there by chemokine interactions between CXCL13, which is secreted by follicular dendritic cells (FDCs).

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#Id: 10351

#Unit 4. Cell Communication and Cell Signaling

B-cell survival in the follicle is dependent on access to the TNF-family member cytokine B-cell activation factor (BAFF), otherwise known as B lymphocyte survival factor (BLyS), which is secreted by the FDCs.

TLS Online TPP Program

#Id: 10352

#Unit 4. Cell Communication and Cell Signaling

B-cell activation

TLS Online TPP Program

#Id: 10353

#Unit 4. Cell Communication and Cell Signaling