Nurturing Life Sciences
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#Unit 2. Cellular Organization
H32-H42 tetramer accounts for the diameter of the octamer. It forms the shape of a horseshoe.
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All four core histones show a similar type of structure in which three a-helices are connected by two loops. This highly conserved structure is called the histone fold.
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Nucleosomes that contain linker H1 histones are referred to as chromatosomes.
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Lysine in the histone tails are the most common targets of modification.
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Acetylation, methylation, ubiquitylation, and sumoylation all occur on the free epsilon amino group of lysine.
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Acetylation neutralizes the positive charge of lysine so disrupts DNA Histone interactions.