TLS Online TPP Program

#Id: 4773

#Unit 5. Developmental Biology

TBX-35 inhibits pal-1 gene expression, preventing the MS cell from acquiring the C-blastomere fates.

TLS Online TPP Program

#Id: 4774

#Unit 5. Developmental Biology

At the 4-cell stage, the EMS cell requires a signal from its neighbor (and sister cell), the P2 blastomere.

TLS Online TPP Program

#Id: 4775

#Unit 5. Developmental Biology

The P2 cell produces the MOM-2 protein, a C. elegans Wnt protein.

TLS Online TPP Program

#Id: 4776

#Unit 5. Developmental Biology

MOM-2 is received in the EMS cell by the MOM-5 protein, a C. elegans protein Frizzled.

TLS Online TPP Program

#Id: 4777

#Unit 5. Developmental Biology

Wnt signaling cascade is to downregulate the expression of the pop-1 gene in the EMS daughter destined to become the E cell.

TLS Online TPP Program

#Id: 4778

#Unit 5. Developmental Biology

If the P2 cell is removed at the early 4-cell stage, the EMS cell will divide into two MS cells, and no endoderm will be produced.