The rate of sedimentation is dependent not only upon the applied centrifugal field, but
also on the nature of the particle, i.e., its density and radius, and also the viscosity of the
surrounding medium. Stokes’ Law describes these relationships for the sedimentation of a
rigid spherical particle:

TLS Online TPP Program

#Id: 705

#Unit 3. Fundamental Processes

Proofreading typically decreases the error rate in replication from10-5 to 10-7 per base pair replicated.

TLS Online TPP Program

#Id: 706

#Unit 3. Fundamental Processes

Repair Systems such as MMR reduces error rate of replication to 10-9 per base pair replicated

TLS Online TPP Program

#Id: 707

#Unit 3. Fundamental Processes

SeqA binds to hemimethylated DNA and is required for delaying rereplication.

TLS Online TPP Program

#Id: 708

#Unit 3. Fundamental Processes

seqA is part of a negative regulatory circuit that prevents origins from being remethylated.

TLS Online TPP Program

#Id: 709

#Unit 3. Fundamental Processes

A locus called dat has a large concentration of DnaA-binding sites. It binds about 80 more DnaA molecules than the origin.

TLS Online TPP Program

#Id: 710

#Unit 3. Fundamental Processes

Deletion of dat causes initiation to occur more frequently. This significantly increases the amount of DnaA available to the origin