seqA is part of a negative regulatory circuit that prevents origins from being remethylated.

TLS Online TPP Program

#Id: 10562

#Unit 4. Cell Communication and Cell Signaling

Activated RIPK1 forms multiprotein complexes via its RHIM domain with the kinase RIPK3, and RIPK3 becomes activated by phosphorylation

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#Id: 10563

#Unit 4. Cell Communication and Cell Signaling

Active RIPK3 phosphorylates the kinase-like domain of the MLKL protein

TLS Online TPP Program

#Id: 10564

#Unit 4. Cell Communication and Cell Signaling

Phosphorylated MLKL form

oligomers that insert into the plasma membrane and form holes, allowing Ca2+ entry.

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#Id: 10565

#Unit 4. Cell Communication and Cell Signaling

Ca2+ influx causes the cell and its organelles to swell

and burst, releasing its contents into the extracellular space which trigger activation of immune-system cells

and cause tissue inflammation and damage

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#Id: 10566

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10567

#Unit 4. Cell Communication and Cell Signaling

Inflammation due to necroptosis has been implicated in mediating major human inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease,

amyotrophic lateral sclerosis, Alzheimer’s disease and progressive atherosclerotic lesions