The conserved function of the replication components extends to the clamp loader and processivity clamp as well other functions of the replisome.

The roles of RFC and PCNA are analogous to the E. coli γ clamp loader and β2 processivity unit

TLS Online TPP Program

#Id: 8386

#Unit 2. Cellular Organization

In the presence of ATP,  myosin head releases from the actin filament. 

TLS Online TPP Program

#Id: 8387

#Unit 2. Cellular Organization

Thick-filament regulation

Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

#Id: 8388

#Unit 2. Cellular Organization

Smooth muscle cells and nonmuscle cells are regulated by:

Norepinephrine, angiotensin, endothelin, histamine

TLS Online TPP Program

#Id: 8389

#Unit 2. Cellular Organization

Smooth muscle contraction is regulated by the cycling of myosin II between on and off states.

TLS Online TPP Program

#Id: 8390

#Unit 2. Cellular Organization

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain activates contraction in Ca2+ dependent manner.

TLS Online TPP Program

#Id: 8391

#Unit 2. Cellular Organization

When the Ca2+ level rises, Ca2+ binds CaM.