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TLS Online TPP Program

#Id: 3238

transversions, which are pyrimidine-to-purine and purine-to-pyrimidine substitutions, such as T to G or A and A to C or T.

#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 10555

#Unit 4. Cell Communication and Cell Signaling

Caspase-8 cleaves and activates several effector caspases, caspase-3, 6, 7 to complete apoptotic cell death.
TLS Online TPP Program

#Id: 10556

#Unit 4. Cell Communication and Cell Signaling

Intrinsic apoptosis pathway
Caspase-8 cleaves the BH3-interacting-domain death agonist (Bid), resulting tBid fragment
TLS Online TPP Program

#Id: 10557

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 10558

#Unit 4. Cell Communication and Cell Signaling

tBid fragment binds to Bcl-2 on the outer mitochondrial membrane, leading to the dissociation of Bak and Bax and release of cytochrome c into the cytosol
TLS Online TPP Program

#Id: 10559

#Unit 4. Cell Communication and Cell Signaling

In cells lacking functional caspase-8 or FADD, TNFα
triggers an alternative pathway, necroptosis.
TLS Online TPP Program

#Id: 10560

#Unit 4. Cell Communication and Cell Signaling