In BER, A DNA glycosylase recognizes a damaged base (in this case, a uracil) and cleaves between the base and deoxyribose in the backbone.

TLS Online TPP Program

#Id: 5534

#Unit 7. System Physiology – Animal

Descending limb of the loop of Henle is permeable to water, due to the presence of aquaporin-1 in both the apical and basolateral membranes

TLS Online TPP Program

#Id: 5535

#Unit 7. System Physiology – Animal

The ascending limb, both the thin & the thick segments is virtually impermeable to water, a characteristic that is important for concentrating the urine.

TLS Online TPP Program

#Id: 5536

#Unit 7. System Physiology – Animal

The thin segment of the ascending limb has a much lower reabsorptive capacity than does the thick segment.

TLS Online TPP Program

#Id: 5537

#Unit 7. System Physiology – Animal

Thick segment of the ascending limb of loop of Henle, has thick epithelial cells that have high metabolic activity and are capable of active reabsorption of sodium, chloride, and potassium

TLS Online TPP Program

#Id: 5538

#Unit 7. System Physiology – Animal

In the thick segment of the ascending loop of Henle  reabsorption mechanism is load-dependent.

TLS Online TPP Program

#Id: 5539

#Unit 7. System Physiology – Animal

In the thick ascending loop,  Luminal membrane contains a three-ion cotransporter  known as Na+-K+-2Cl- cotransporter