Alternative models for translesion synthesisIn; Two models explain the mechanism of translesion synthesis, each likely to be true under particular circumstances.

The polymerase-switching model,

The gap-filling model,

TLS Online TPP Program

#Id: 6155

#Unit 3. Fundamental Processes

Human member of the Y family of translesion polymerases (DNA Pol n) correctly inserts two A residues opposite a thymine dimer. 

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#Id: 1271

#Unit 7. System Physiology – Animal

The zona glomerulosa is controlled via; Renin-angiotensin-aldosterone system. 

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#Id: 7499

#Unit 4. Cell Communication and Cell Signaling

VpreB and λ5 (called a surrogate light chain), to form a pre-B-cell receptor.

TLS Online TPP Program

#Id: 6031

#Unit 3. Fundamental Processes

In mammalian systems where the DNA polymerase does not have a 5’–3’ exonuclease activity, Okazaki fragments are connected by a two-step process. 

TLS Online TPP Program

#Id: 1482

#Unit 4. Cell Communication and Cell Signaling

Neurofibromatosis, a benign tumor of the sheath cells that surround nerves, is caused by loss of both alleles of NF1, which encodes a RAS GAP-type protein.