Alternative models for translesion synthesisIn; Two models explain the mechanism of translesion synthesis, each likely to be true under particular circumstances.

The polymerase-switching model,

The gap-filling model,

TLS Online TPP Program

#Id: 687

#Unit 3. Fundamental Processes

Elimination of Shelterin leads to the recognition of the telomeres as normal DNA breaks.

TLS Online TPP Program

#Id: 688

#Unit 3. Fundamental Processes

Telomeres form a looped structure in the cell called as t-loop

TLS Online TPP Program

#Id: 689

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 690

#Unit 3. Fundamental Processes

t-loop is formed by the 3’-ssDNA end of the telomere invading the dsDNA region of the telomere

TLS Online TPP Program

#Id: 691

#Unit 3. Fundamental Processes

TRF2 is capable of directing t-loop formation with purified telomere DNA.

TLS Online TPP Program

#Id: 692

#Unit 3. Fundamental Processes

Mutants that used to analyse Replication Machinery are usually Conditional Lethals