Pointers

  1. Home
  2. Free Resources
  3. Pointers
  4. 3419
TLS Online TPP Program

#Id: 3419

Ku70 and Ku80 are the most fundamental components of NHEJ. They constitute a heterodimer that binds to the DNA ends and recruits DNA-PKcs, which is a protein kinase

#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
PYQ Links
  1. PYQ 1
Extensive Links
  1. Link 1
More Pointers
TLS Online TPP Program

#Id: 9476

#Unit 4. Cell Communication and Cell Signaling

SOCS proteins 
expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods
TLS Online TPP Program

#Id: 9477

#Unit 4. Cell Communication and Cell Signaling

All SOCS proteins contains:
SH2 domain
SOCS box
TLS Online TPP Program

#Id: 9478

#Unit 4. Cell Communication and Cell Signaling

SOCS box, 
Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome
TLS Online TPP Program

#Id: 9479

#Unit 4. Cell Communication and Cell Signaling

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity
TLS Online TPP Program

#Id: 9480

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 9481

#Unit 4. Cell Communication and Cell Signaling