In the absence of insulin, the extracellular domain adopts a symmetric inverted U-shaped conformation. 

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#Unit 5. Developmental Biology

Commitment

The commitment of cells to specific cell fates & their capacity to differentiate into particular kinds of cells (cell has began in a direction towards a specific fate).

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#Id: 85

#Unit 5. Developmental Biology

Commitment

At this stage the cell or tissue does not appear phenotypically different from its uncommitted state, its developmental fate has become restricted.

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#Id: 86

#Unit 5. Developmental Biology

Stages of commitment- 

1- Specification 

2- Determination

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#Id: 87

#Unit 5. Developmental Biology

Cell Specification

cells become specified to a specific fate

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#Unit 5. Developmental Biology

Specification (capable of being altered)

It is a labile phase, so it is not fixed.

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#Unit 5. Developmental Biology

There are three different modes of cell specification: 

1. Autonomous

2. Conditional

3. Syncytial