CSIR-PYQ Concept

Delta rhythm (<4 Hz)

slow-wave sleep 

high-amplitude waves

TLS Online TPP Program

#Id: 9470

#Unit 4. Cell Communication and Cell Signaling

Phosphorylated STAT dissociates spontaneously from the receptor, and two phosphorylated STAT proteins form a homodimer.

TLS Online TPP Program

#Id: 9471

#Unit 4. Cell Communication and Cell Signaling

STAT5 becomes activated in erythroid progenitor cells and induces expression of the protein Bcl-xL.

TLS Online TPP Program

#Id: 9472

#Unit 4. Cell Communication and Cell Signaling

Two mechanisms for terminating cytokine signaling:

1. Short-term regulation: SHP1

2. Long-term regulation: SOCS proteins

TLS Online TPP Program

#Id: 9473

#Unit 4. Cell Communication and Cell Signaling

SHP1 a phosphotyrosine phosphatase, contains:

SH2 domain  & Phosphatase domain

TLS Online TPP Program

#Id: 9474

#Unit 4. Cell Communication and Cell Signaling

SHP1 

Binding of an SH2 domain to a phosphotyrosine in the activated receptor unmasks its phosphatase catalytic site

TLS Online TPP Program

#Id: 9475

#Unit 4. Cell Communication and Cell Signaling

SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.