STAT5 becomes activated in erythroid progenitor cells and induces expression of the protein Bcl-xL.

TLS Online TPP Program

#Id: 10051

#Unit 4. Cell Communication and Cell Signaling

The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain

TLS Online TPP Program

#Id: 10052

#Unit 4. Cell Communication and Cell Signaling

Second cleavage of Notch occurs within membrane-spanning region & catalyzed by γ-secretase

TLS Online TPP Program

#Id: 10053

#Unit 4. Cell Communication and Cell Signaling

γ-secretase complex contains 

Presenilin 1 (actual protease), aph-1, pen-2, & nicastrin

TLS Online TPP Program

#Id: 10054

#Unit 4. Cell Communication and Cell Signaling

Cleavage by the γ-secretase complex releases the Notch cytosolic segment, which translocates to the nucleus, interacts with a single DNA-binding transcription factor, CSL.

TLS Online TPP Program

#Id: 10055

#Unit 4. Cell Communication and Cell Signaling

Growth factors and EGFs are synthesized as TM proteins, regulated cleavage of the precursor by members of the ADAM protease releases the active molecule into the extracellular space.

TLS Online TPP Program

#Id: 10056

#Unit 4. Cell Communication and Cell Signaling

Cell-adhesion molecules (CAMs) mediate direct cell-cell adhesions.