Gene Interaction with Epistasis

The effect of gene interaction is that one gene masks (hides) the effect of another gene at a different locus.

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#Id: 2956

#Unit 3. Fundamental Processes

ORC is an initiation complex whose binding identifies an origin of replication.

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#Id: 2957

#Unit 3. Fundamental Processes

The yeast ARS elements satisfy the classic definition of an origin as a cis-acting sequence that causes DNA replication to initiate.

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#Id: 2958

#Unit 3. Fundamental Processes

Reconciliation between this phenomenon and the use of ORCs is suggested by the discovery that environmental effects can influence the use of origins.

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#Id: 2959

#Unit 3. Fundamental Processes

A nucleus injected into a Xenopus egg can replicate only once unless the nuclear membrane is permeabilized to allow subsequent replication cycles

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#Id: 2960

#Unit 3. Fundamental Processes

ORC is a protein complex that is associated with yeast origins throughout the cell cycle.

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#Id: 2961

#Unit 3. Fundamental Processes

The key event in controlling replication is the behavior of the ORC complex at the origin.

Cdc6 protein is an unstable protein that is synthesized only in G1.

Cdc6 binds to ORC and allows MCM proteins.

Cdc6 binds to ORC and allows MCM proteins to bind.

Cdt1 facilitates MCM loading on origins