Conducting cells constitute tissues of the SA node, the atrial internodal tracts, the AV node, the bundle of His, & the Purkinje system.

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#Unit 4. Cell Communication and Cell Signaling

Rous sarcoma virus is a retrovirus whose RNA genome is reverse transcribed into DNA, which is incorporated into the host-cell genome

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#Unit 4. Cell Communication and Cell Signaling

Oncogenic transforming viruses RSV contain an

oncogene — v-src gene

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#Unit 4. Cell Communication and Cell Signaling

Avian leukosis virus (ALV), 

Retroviral DNA is inserted near the MYC gene. overproduction of MYC causes abnormally rapid proliferation of cells.

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#Unit 4. Cell Communication and Cell Signaling

Human papillomavirus encodes two oncogenic proteins: E6 -inhibits p53

E7- inhibits RB

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#Unit 4. Cell Communication and Cell Signaling

Chromosomal translocation 

That fuses two genes together to produce a hybrid gene encoding a chimeric protein whose activity is constitutive

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#Unit 4. Cell Communication and Cell Signaling

Chromosomal translocation 

That brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene