The mark-recapture technique is that after the tagged animals are released, they mix freely with unmarked individuals. The population is resampled and the numbers of marked and unmarked individuals are recorded. 

TLS Online TPP Program

#Id: 1572

#Unit 4. Cell Communication and Cell Signaling

Kinases CK1 and GSK3,

sequentially phosphorylate β-catenin at multiple serine and threonine residues.

TLS Online TPP Program

#Id: 1573

#Unit 4. Cell Communication and Cell Signaling

The E3 TrCP ubiquitin ligase then binds to two phosphorylated β-catenin residues, leading to β-catenin ubiquitinylation and degradation in proteasomes.

TLS Online TPP Program

#Id: 1574

#Unit 4. Cell Communication and Cell Signaling

Binding of Wnt to its receptor Frizzled (Fz) and to the LRP co-receptor triggers phosphorylation of LRP by GSK3 and CK1, enables Axin to bind LRP & Dsh.

 

TLS Online TPP Program

#Id: 1575

#Unit 4. Cell Communication and Cell Signaling

Binding of Axin to the phosphorylated LRP protein and to Dishevelled disrupts the Axin–APC–CK1–GSK3–β-catenin complex. 

TLS Online TPP Program

#Id: 1576

#Unit 4. Cell Communication and Cell Signaling

Unphosphorylated β-catenin translocates to the nucleus.

TLS Online TPP Program

#Id: 1577

#Unit 4. Cell Communication and Cell Signaling

β-catenin binds to TCF to displace the Gro repressor and recruits co-activator proteins Pygo, LGS, to activate target gene expression.